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Urocit®-K inhibits stone formation with a broad range of efficacy

Urocit®-K is indicated for the management of renal tubular acidosis (RTA) with calcium stones, hypocitraturic calcium oxalate nephrolithiasis of any etiology, and uric acid lithiasis with or without calcium stones.

Urocit®-K is effective in:
Metabolic Cause Stone Composition
hypocitraturia calcium oxalate
hyperuricosuria calcium oxalate
idiopathic uric acid nephrolithiasis uric acid
hypercalciuria calcium oxalate
undue urinary acidity uric acid
renal tubular acidosis calcium oxalate
Table 1

Urocit®-K increases urinary citrate and urinary pH1-3

Urocit®-K alkalinizes the urine. The citrate moiety, which is largely oxidized, is absorbed while the K ion remains, leaving an alkali load. The alkali load increases urinary citrate (inhibiting crystallization) and urinary pH (contributing to retardation of crystallization of calcium salts and inhibition of uric acid crystallization). Urocit®-K decreases urinary saturation of calcium oxalate and inhibits both calcium oxalate and its crystallization.

Urocit®-K inhibits stone formation in more than 90% of patients3,7,8

Urocit®-K produces remission (cessation of stone formation) in over 70% of patients.3,7,8

  Renal Tubular Acidosis Chronic Diarrheal Syndrome Idiopathic Hypocitraturia Uric Acid Stones
Pre-Treatment
Duration (yr/pt)
3 3 3 3
Stone Formation
Rate (no./yr)
39.3 4.69 2.11 1.20
Treatment
Duration (yr/pt)
2.83 3.2 2.13 2.78
Stone Formation
Rate (no./yr)
0* 0.71* 0.28* 0.01*
Remission (%) 100 70 89 94
Reduced Stone
Formation
Rate (%)
100 90 100 100

Urocit®-K is contraindicated in patients with hyperkalemia and/or renal insufficiency.

* p<0.01

Table 2
This material is intended to provide basic information. Patients should discuss all medical advice, diagnosis, and treatment with their healthcare provider.

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